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How to handle replies to cold outreach (unsubscribes, bounces)

Every cold campaign ends the same way: a pile of replies, most of them not "yes". Each kind needs a different action, and the costly mistakes are one-sided: messaging someone who asked you to stop, or chasing a bounced address. The rule of thumb is that doing less is always safe and doing more needs a decision.

Open the free inbox agent

The safe action for each reply

ReplyDo straight awayNeeds a person
Unsubscribe / stopStop all contact; add to a suppression list with the date and their wordsNothing; no reply
BounceStop email to that addressFinding a correct address from your own records
Out of officePause until the business day after they return (a week if no date)A task if it names another contact
Left the company / wrong personStop the cadence for that contactWhether to add the person they named
Not interestedStop; do not suggest again for 180 daysNothing
Not nowPause until their date (90 days if none)A short acknowledgement
Objection or questionPause the cadenceThe answer, which only you can give
InterestedStop the automated cadence; log a dealThe reply with your booking link

Why keep the opt-out record

A suppression list is only useful if it survives the next import. Store the address, the date and the sentence they wrote. If anyone later asks why you wrote to them, or whether you honoured their request, the record answers. In the US, CAN-SPAM requires an opt-out to be honoured within 10 business days; treating it as immediate is simpler and safer.

Doing this by hand, or with the inbox agent

You can run the table above in a spreadsheet. The sales agent's inbox milestone does the same bookkeeping from pasted replies: it classifies each one, applies only the actions that reduce contact, writes the suppression, prospect and deal rows, and queues drafts for you to approve. It runs in your browser with nothing uploaded, and sends nothing. Its rules read only part of real replies; the measured accuracy and the labelled test sets are in the README.

Try it on your own replies

Questions

What should I do with an unsubscribe reply to cold email?

Stop every further message to that address straight away and keep a record: the address, the date and their own words. In the US, the CAN-SPAM Act requires honouring an opt-out within 10 business days; other places (the EU and UK, Canada) have their own rules. Do not reply to argue, and do not re-add them from another list.

How long should I wait after an out-of-office reply?

Until the business day after the return date the auto-reply gives. If it names no date, the sales agent waits one week. An auto-reply is not a refusal, so the prospect is paused, not removed.

What do I do with a 'not now, try next quarter' reply?

Pause the prospect until the date they gave and send, at most, a short acknowledgement. With no date the sales agent pauses for 90 days. Write the follow-up date down so it happens.

Does the sales agent send replies for me?

No. It stops or pauses contact on its own, because those only reduce what is sent, and queues everything else as a draft for you to approve. It sends nothing.

Can it be wrong about what a reply means?

Yes. Its rules read only part of real replies; the measured numbers are in the project README. Anything it is unsure of goes to you as an 'unclear' reply and nothing is done on a guess.